Saturday, July 9, 2011

Advanced Paternal Age

There is a known increase in risk of chromosomal malformations, including Down syndrome, with advanced maternal age. But research in recent years suggests that the increase in risk of ASD is associated with advanced paternal age. The hypothesis is that there are more opportunities for copy number mutations to occur in the sperm of older fathers. Current research aims at modelling this in rodents. Australian researchers describe this attempt here.


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